Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Physiological plans and you may pharmacology off curcumin
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the biggest component of the latest reddish color out-of turmeric, an enthusiastic Indian spice that is taken from the new rhizome of your own tropical bush Curcuma longa, and that is one of the Zingiberaceae friends. In this section, we talk about the pharmacological factors off curcumin and you can discuss the brand new unit basics of these factors. We upcoming review the newest proven and you can prospective logical spends away from curcumin. Curcumin known typically once the a therapeutic representative, but their device of action is detail by detail. This new pharmacological effects of curcumin seem to be caused by good synergism away from networking sites from weak biochemical connections which have multiple physiological targets in the interrelated signaling routes. Such aim include minerals such cyclooxygenase, lipoxygenase and you may healthy protein kinases, and you will transcription products particularly NF-?B, STAT and you may Nrf2. Modulation ones particles impacts downstream affectors which make the newest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial facts out of curcumin. These types of effects have been looked at within the medical samples from curcumin having serious pain and you will inflammatory diseases, cancer tumors, Alzheimer state, cardio illness, and you will diabetes. The fresh new products purchased variable amounts off curcuminwith some other wavelengths and you will duration, toward standard conclusion you to definitely large dosages of curcumin at level of g have to obtain healing outcomes. Find out more
Curcumin: Synthesis, Growing Role in Serious pain Administration and Wellness Implications
Guide Section Samples of plant-derived pharmaceuticals which have get to be the attract of persisted and great lookup and you may development interest features, thus far, come some scarce. Once several years, the past two decades had been characterized by a great 100-bend boost in just how many medical posts had written a year that try off benefits towards the access to curcumin within the biomedicine. Find out more
Framework, synthesis and you can physiological situations away from curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some possible pharmacological effects and may has therapeutic applications in many problem says, because the discussed in more detail in the last section. However, the potential medical effectiveness out-of curcumin is restricted by its physicochemical qualities off terrible liquid solubility and you will instability, and this result in low bioavailability. Prodrugs off curcumin give a method to improvement of your own biopharmaceutical and you will pharmacokinetic functions, and may also make it exploitation of your own pharmacological aftereffects of curcumin. Inside part, we very first feedback the fresh new physicochemical and you will pharmacokinetics of curcumin. I then establish the appearance of curcumin prodrugs having improved drinking water solubility and you will improved chemicals balances which might be translated back into free curcumin through to bioactivation inside the vivo. We stress present achievement in this area, which have a concentrate on the design, synthesis and you may testing out of prodrugs predicated on promoieties including proteins, fatty bravodate webbplats Г¤kta? acids, nucleic acids, dicarboxylic acids, and you can polymeric content such as for example hyaluronic acid and you can polyethylene glycol. It section has the reason for optimisation of your physicochemical and you can biopharmaceutical functions and the physical factors regarding curcumin prodrugs, for the mission playing with of them curcumin types when you look at the scientific software. Find out more